吕洪水
发布时间: 2017-05-11 浏览次数: 13

姓名

吕洪水

性别

出生年月

1985.09

籍贯

山东德州

政治面貌

群众

学历、学位

研究生,博士

行政职务

专业技术职务

  

专业

有机化学

办公地点

2号教学楼B204

导师类别

  

  

  

通讯方式

lvhongshui@aliyun.com

隶属单位

齐鲁工业大学,轻工学部,造纸与植物资源工程学院,分析测试中心

通讯地点

山东省济南市长清区大学路3501号,邮编:250353

个人简历:

2004.9-2008.6 山东大学化学与化工学院 化学 学士

2008.9-2013.6山东大学化学与化工学院 有机化学 博士

2013.7-2016.7康龙化成(北京)新药技术有限公司

2016.8-2016.9甘李药业股份有限公司

2016.11-2017.4北京加科思新药研发有限公司

2017.5至今齐鲁工业大学分析测试中心

研究方向:

药物化学,荧光探针,有机合成

主要科研类业绩与成果:

1.Hong-Shui Lv, Shu-Ya Huang, Yu Xu, Xi Dai,   Jun-Ying Miao*, Bao-Xiang Zhao, A new fluorescent pH probe for imaging   lysosomes in living cells. Bioorganic   & Medicinal Chemistry Letters, 2014, 24, 535–538.

2.Hong-Shui Lv, Shu-Ya Huang, Bao-Xiang Zhao,   Jun-Ying Miao, A new rhodamine B-based lysosomal pH fluorescent indicator, Analytica Chimica Acta, 2013, 788,   177-182.

3. Hong-Shui Lv, Jing Liu, Jing Zhao,   Bao-Xiang Zhao, Jun-Ying Miao, Highly selective and sensitive pH-responsive fluorescent   probe in living HeLa and HUVEC cells, Sensors   & Actuators, B: Chemical, 2013, 177, 956–963.

4.Hong-Shui   Lv, Li-Ying Wang, Xiao-Ling Ding, Xiu-Hua Wang, Hua Zuo, Bao-Xiang Zhao, Synthesis and antifungal   activity of novel   (1-arylmethyl-3-aryl-1Hpyrazol-5-yl)(4-arylpiperazin-1-yl)methanone   derivatives, Journal of Chemical   Research, 2013, 473-475.

5. Hong-Shui Lv, Jin-Hua Zhang, Yong-Sheng Xie,   Bao-Xiang Zhao, Synthesis and x-ray crystal structure of novel (3E,4E)-1-aryl-3,4-bis[(benzo[d][1,3]dioxol-5-yl)methylidene]pyrrolidene-2,5-dione,   Journal of Chemical Research, 2013,   362-364.

6. Hong-Shui Lv, Xiao-Ling Ding, Bao-Xiang   Zhao, Synthesis and x-ray structure characterization of novel pyrazole   carboxamide derivatives, Journal of   Chemical Research, 2013, 223-226.

7. Hong-Shui Lv, Qian-Qian Han,   Xiao-Ling Ding, Ji-Liang Zhou, Pi-Shan Yang, Jun-Ying Miao, and Bao-Xiang Zhao,   Synthesis and discovery of novel pyrazole carboxamide derivatives as potential   osteogenesis inducers. Archiv der   Pharmazie, 2012, 345(11), 870–877.

8. Hong-Shui Lv, Xiang-Qian Kong,   Qian-Qian Ming, Xing Jin, Jun-Ying Miao, Bao-Xiang Zhao, Synthesis of   5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-   4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for   H322 lung cancer cell. Bioorganic &   Medicinal Chemistry Letters, 2012, 22(2), 844–849.

9. Hong-Shui Lv, Yong-Sheng Xie,   Wei-Yong Liu, Zhong-Liang Gong, Bao-Xiang Zhao, Synthesis, x-ray crystal   structures and optical properties of novel substituted pyrazoly   1,3,4-oxadiazole derivatives. Journal   of Fluorescence, 2011, 21(4), 1797–1804.

10. Hong-Shui Lv, Bao-Xiang Zhao, Ji-Kun   Li, Yong Xia, Song Lian, Wei-Yong Liu, Zhong-Liang Gong, The synthesis,   characterization and optical properties of novel, substituted, pyrazoly   1,3,4-oxadiazole derivatives. Dyes and   Pigments, 2010, 86(1), 25–31.

  

专利:

1.一种含1,3,4-噁二唑结构单元的罗丹明BpH荧光探针及应用

2.吡唑并吡嗪二酮衍生物及其应用

3.一种含半胱氨酸乙酯结构的罗丹明B类靶向溶酶体pH荧光探针及应用



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