姓名 | 吕洪水 | 性别 | 男 | 出生年月 | 1985.09 |
籍贯 | 山东德州 | 政治面貌 | 群众 | 学历、学位 | 研究生,博士 |
行政职务 | 无 | 专业技术职务 |
| 专业 | 有机化学 |
办公地点 | 2号教学楼B204 | 导师类别 |
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通讯方式 | lvhongshui@aliyun.com | ||||
隶属单位 | 齐鲁工业大学，轻工学部，造纸与植物资源工程学院，分析测试中心 | ||||
通讯地点 | 山东省济南市长清区大学路3501号，邮编：250353 | ||||
个人简历： 2004.9-2008.6 山东大学化学与化工学院 化学 学士 2008.9-2013.6山东大学化学与化工学院 有机化学 博士 2013.7-2016.7康龙化成（北京）新药技术有限公司 2016.8-2016.9甘李药业股份有限公司 2016.11-2017.4北京加科思新药研发有限公司 2017.5至今齐鲁工业大学分析测试中心 | |||||
研究方向： 药物化学，荧光探针，有机合成 | |||||
主要科研类业绩与成果： 1.Hong-Shui Lv, Shu-Ya Huang, Yu Xu, Xi Dai, Jun-Ying Miao*, Bao-Xiang Zhao, A new fluorescent pH probe for imaging lysosomes in living cells. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 535–538. 2.Hong-Shui Lv, Shu-Ya Huang, Bao-Xiang Zhao, Jun-Ying Miao, A new rhodamine B-based lysosomal pH fluorescent indicator, Analytica Chimica Acta, 2013, 788, 177-182. 3. Hong-Shui Lv, Jing Liu, Jing Zhao, Bao-Xiang Zhao, Jun-Ying Miao, Highly selective and sensitive pH-responsive fluorescent probe in living HeLa and HUVEC cells, Sensors & Actuators, B: Chemical, 2013, 177, 956–963. 4.Hong-Shui Lv, Li-Ying Wang, Xiao-Ling Ding, Xiu-Hua Wang, Hua Zuo, Bao-Xiang Zhao, Synthesis and antifungal activity of novel (1-arylmethyl-3-aryl-1Hpyrazol-5-yl)(4-arylpiperazin-1-yl)methanone derivatives, Journal of Chemical Research, 2013, 473-475. 5. Hong-Shui Lv, Jin-Hua Zhang, Yong-Sheng Xie, Bao-Xiang Zhao, Synthesis and x-ray crystal structure of novel (3E,4E)-1-aryl-3,4-bis[(benzo[d][1,3]dioxol-5-yl)methylidene]pyrrolidene-2,5-dione, Journal of Chemical Research, 2013, 362-364. 6. Hong-Shui Lv, Xiao-Ling Ding, Bao-Xiang Zhao, Synthesis and x-ray structure characterization of novel pyrazole carboxamide derivatives, Journal of Chemical Research, 2013, 223-226. 7. Hong-Shui Lv, Qian-Qian Han, Xiao-Ling Ding, Ji-Liang Zhou, Pi-Shan Yang, Jun-Ying Miao, and Bao-Xiang Zhao, Synthesis and discovery of novel pyrazole carboxamide derivatives as potential osteogenesis inducers. Archiv der Pharmazie, 2012, 345(11), 870–877. 8. Hong-Shui Lv, Xiang-Qian Kong, Qian-Qian Ming, Xing Jin, Jun-Ying Miao, Bao-Xiang Zhao, Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin- 4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cell. Bioorganic & Medicinal Chemistry Letters, 2012, 22(2), 844–849. 9. Hong-Shui Lv, Yong-Sheng Xie, Wei-Yong Liu, Zhong-Liang Gong, Bao-Xiang Zhao, Synthesis, x-ray crystal structures and optical properties of novel substituted pyrazoly 1,3,4-oxadiazole derivatives. Journal of Fluorescence, 2011, 21(4), 1797–1804. 10. Hong-Shui Lv, Bao-Xiang Zhao, Ji-Kun Li, Yong Xia, Song Lian, Wei-Yong Liu, Zhong-Liang Gong, The synthesis, characterization and optical properties of novel, substituted, pyrazoly 1,3,4-oxadiazole derivatives. Dyes and Pigments, 2010, 86(1), 25–31.
专利： 1.一种含1,3,4-噁二唑结构单元的罗丹明B类pH荧光探针及应用 2.吡唑并吡嗪二酮衍生物及其应用 3.一种含半胱氨酸乙酯结构的罗丹明B类靶向溶酶体pH荧光探针及应用 | |||||
